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Drug Discovery

Marine-derived oncology compounds — library, dose-response, and screening.

Compound Library (7)
Pyrethrin I structurePubChem CID 2999397 →

Pyrethrin I

Voltage-gated Na⁺ channel modulator (type I pyrethroid). Prolongs open state of insect Nav channels (DmNav/para); rapid knockdown at low concentrations. Selective for insect vs mammalian Nav due to temperature-dependent channel kinetics.

MW: 328.44
logP: 5.9
HBD: 0
HBA: 3
TPSA: 43
Stage: Preclinical

Origin: Chrysanthemum cinerariifolium (pyrethrum flower)

Dose-Response (4PL)
0501001e-41e-31e-21e-11e01e1Concentration (µM, log)
IC50 (µM)
1.00
Hill slope
1.30
R²
0.975
Selectivity idx
1.0
Screening Heatmap — log₁₀(IC50 µM)
DMS-114H446SW872OVCAR3MCF-7HCT116MRC-5HUVECPyrethrin IPyrethrin I × DMS-114 (SCLC): log10(IC50)=0.00Pyrethrin I × H446 (SCLC): log10(IC50)=0.00Pyrethrin I × SW872 (DDLPS): log10(IC50)=0.00Pyrethrin I × OVCAR3 (Ovarian): log10(IC50)=0.00Pyrethrin I × MCF-7 (Breast): log10(IC50)=0.00Pyrethrin I × HCT116 (CRC): log10(IC50)=0.00Pyrethrin I × MRC-5 (Normal): log10(IC50)=0.00Pyrethrin I × HUVEC (Normal): log10(IC50)=0.00TrabectedinTrabectedin × DMS-114 (SCLC): log10(IC50)=-2.92Trabectedin × H446 (SCLC): log10(IC50)=-3.10Trabectedin × SW872 (DDLPS): log10(IC50)=-3.46Trabectedin × OVCAR3 (Ovarian): log10(IC50)=-2.82Trabectedin × MCF-7 (Breast): log10(IC50)=-2.35Trabectedin × HCT116 (CRC): log10(IC50)=-2.05Trabectedin × MRC-5 (Normal): log10(IC50)=-0.92Trabectedin × HUVEC (Normal): log10(IC50)=-0.74LurbinectedinLurbinectedin × DMS-114 (SCLC): log10(IC50)=-3.05Lurbinectedin × H446 (SCLC): log10(IC50)=-3.22Lurbinectedin × SW872 (DDLPS): log10(IC50)=-2.60Lurbinectedin × OVCAR3 (Ovarian): log10(IC50)=-2.96Lurbinectedin × MCF-7 (Breast): log10(IC50)=-2.42Lurbinectedin × HCT116 (CRC): log10(IC50)=-2.14Lurbinectedin × MRC-5 (Normal): log10(IC50)=-1.02Lurbinectedin × HUVEC (Normal): log10(IC50)=-0.85EcubectedinEcubectedin × DMS-114 (SCLC): log10(IC50)=-2.68Ecubectedin × H446 (SCLC): log10(IC50)=-2.74Ecubectedin × SW872 (DDLPS): log10(IC50)=-2.28Ecubectedin × OVCAR3 (Ovarian): log10(IC50)=-2.47Ecubectedin × MCF-7 (Breast): log10(IC50)=-2.05Ecubectedin × HCT116 (CRC): log10(IC50)=-1.82Ecubectedin × MRC-5 (Normal): log10(IC50)=-0.51Ecubectedin × HUVEC (Normal): log10(IC50)=-0.38MEX-2341MEX-2341 × DMS-114 (SCLC): log10(IC50)=-1.35MEX-2341 × H446 (SCLC): log10(IC50)=-1.42MEX-2341 × SW872 (DDLPS): log10(IC50)=-1.54MEX-2341 × OVCAR3 (Ovarian): log10(IC50)=-1.92MEX-2341 × MCF-7 (Breast): log10(IC50)=-1.64MEX-2341 × HCT116 (CRC): log10(IC50)=-1.17MEX-2341 × MRC-5 (Normal): log10(IC50)=-0.06MEX-2341 × HUVEC (Normal): log10(IC50)=0.08PlitidepsinPlitidepsin × DMS-114 (SCLC): log10(IC50)=-2.05Plitidepsin × H446 (SCLC): log10(IC50)=-1.92Plitidepsin × SW872 (DDLPS): log10(IC50)=-1.01Plitidepsin × OVCAR3 (Ovarian): log10(IC50)=-1.60Plitidepsin × MCF-7 (Breast): log10(IC50)=-1.82Plitidepsin × HCT116 (CRC): log10(IC50)=-1.51Plitidepsin × MRC-5 (Normal): log10(IC50)=-0.35Plitidepsin × HUVEC (Normal): log10(IC50)=-0.17SYL-1801SYL-1801 × DMS-114 (SCLC): log10(IC50)=-0.66SYL-1801 × H446 (SCLC): log10(IC50)=-0.74SYL-1801 × SW872 (DDLPS): log10(IC50)=-0.47SYL-1801 × OVCAR3 (Ovarian): log10(IC50)=-0.92SYL-1801 × MCF-7 (Breast): log10(IC50)=-1.11SYL-1801 × HCT116 (CRC): log10(IC50)=-1.05SYL-1801 × MRC-5 (Normal): log10(IC50)=0.32SYL-1801 × HUVEC (Normal): log10(IC50)=0.53
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